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Science News European Space Agency Gizmag SciTech Daily Massachusetts Institute of Technology - MIT ScienceNews, Phys. Science News European Space Agency Gizmag SciTech Daily Massachusetts Institute of Technology - MIT ScienceNews, Phys. Deep coma with absent brain stem reflexes may mimic brain death in overdose. Deep coma with absent brain stem reflexes may mimic brain death in overdose. There is no specific antidote for treating overdoses of Baclofen Injection; however, the following steps should ordinarily be undertaken: 1) Residual intrathecal baclofen solution should be removed from the pump as soon as possible. There is no specific antidote for treating overdoses of Baclofen Injection; however, the following steps should ordinarily be undertaken: 1) Residual intrathecal baclofen solution should be removed from the pump as soon as possible. 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In three cases, intravenous physostigmine (2 mg) completely reversed the respiratory depression and coma caused by boluses of 80 to 800 micrograms of lumbar intrathecal baclofen. In three cases, intravenous physostigmine (2 mg) completely reversed the respiratory depression and coma caused by boluses of 80 to 800 micrograms of lumbar intrathecal baclofen. Similar toxicity is not expected with intrathecal use of baclofen as resultant drug plasma concentrations are 100-fold. Similar toxicity is not expected with intrathecal use of baclofen as resultant drug plasma concentrations are 100-fold. Drug Name: Brand or Common Name of the HCPCS code Authorization Required: If there is a check mark in this column then there is No Authorization Required Not Covered: If there is a check mark in this column, then. 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